In order to solve the problem of dynamic response of the support of the curved cable-stayed bridge of semi-floating steel box girder under the action of moving vehicles, the right width of the No.1 bridge of the main line of Taizicheng interchange was taken as the research object, the bridge model was established based on the finite element software ABAQUS, the moving load was used to simulate the driving process of the vehicle on the bridge, different vehicle speeds, different levels of bridge deck unevenness and eccentric load conditions were set, and the influence of moving vehicles on the bearing stress at the junction of the tower girder was explored, so as to provide reference opinions for the design and maintenance of related bridge types. The results show that the stress on the outer support is slightly greater than that on the inner support. In view of the large radius of curvature of the bridge, the speed of the moving vehicle has little influence on the bearing stress, while the unevenness of the bridge deck and the eccentric load of the vehicle have a great influence on the bearing stress. At the same time, under the condition of internal and external eccentric load, the peak stress response of the support is almost unchanged, and the bridge is not prone to the phenomenon of the main girder rollover.